Premium
The study on the degradation and mineralization mechanism of ion‐doped calcium polyphosphate in vitro
Author(s) -
Song Wei,
Tian Meng,
Chen Feng,
Tian Yefei,
Wan Changxiu,
Yu Xixun
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31230
Subject(s) - mineralization (soil science) , polyphosphate , ionic radius , doping , calcium , ion , ionic bonding , simulated body fluid , materials science , chemistry , mineralogy , metallurgy , phosphate , apatite , biochemistry , optoelectronics , organic chemistry , nitrogen
Doping with different trace elements can significantly change the original degradability, mineralization, and biological properties of bone repair material. According to the fundamental research on prepared calcium polyphosphate (CPP) as a bone repair material by our group, this article began further exploration on the effect of doping different trace elements (K, Na, Mg, Zn, Sr) into CPP on its degradability and mineralization soaking in simulated body fluids. The results indicated that doped elements significantly changed the lattice parameters and cell volume of crystal, resulted in different types of crystal defect and surface charge distribution, and consequently changed the original degradability and mineralization of CPP. The conclusion is that doped ions with relatively smaller ionic radius and equivalent positive charge compared with Ca 2+ can greatly promote the degradability and mineralization of CPP, whereas doped ions with equivalent ionic radius and diverse positive charges compared with Ca 2+ provide less contribution on promoting the degradability and mineralization or even counteract. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009