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Protein adsorption resistance and oxygen permeability of chemically crosslinked phospholipid polymer hydrogel for ophthalmologic biomaterials
Author(s) -
Goda Tatsuro,
Matsuno Ryosuke,
Konno Tomohiro,
Takai Madoka,
Ishihara Kazuhiko
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31204
Subject(s) - self healing hydrogels , oxygen permeability , protein adsorption , phosphorylcholine , chemical engineering , polymer , polymer chemistry , adsorption , contact angle , wetting , materials science , chemistry , swelling , permeability (electromagnetism) , oxygen , organic chemistry , membrane , biochemistry , engineering
Abstract The biomimetic structure of a polymer hydrogel bearing phosphorylcholine groups was obtained from 2‐methacryloyloxyethylphosphorylcholline (MPC) and a novel crosslinker, 2‐(methacryloyloxy)ethyl‐ N ‐(2‐methacryloyloxy)ethyl]phosphorylcholine (MMPC), to prepare biocompatible ocular materials. MMPC is a dimethacrylate with phosphorylcholine‐analogous linkage. Previous reports clarified that the affinity of MMPC to MPC enables the water contents and mechanical properties of the poly(MPC) hydrogels to be varied without disturbing the bulk phases. In this study, we examined the protein adsorption resistance, water wettability, oxygen permeability, and electrolyte permeability of the mechanically enhanced poly(MPC) hydrogel crosslinked with MMPC. The amount of protein adsorbed on this hydrogel was 0.9 μg/cm 2 , which accounted for 30% of Omafilcon A and 3% of Etafilcon A. Water contact angle experiments revealed the high wettability of the poly(MPC) hydrogels. The oxygen permeability and NaCl diffusion constant of the poly(MPC) hydrogels were 64 barrer and 48 × 10 −6 cm 2 /s, respectively. This high permeability resulted from the high water content, similar to the case of the human cornea. These results suggested that poly(MPC) hydrogels have good potential for use in ophthalmologic biomaterials. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009