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MBG/PLGA composite microspheres with prolonged drug release
Author(s) -
Li Xia,
Wang Xiupeng,
Zhang Lingxia,
Chen Hangrong,
Shi Jianlin
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31197
Subject(s) - materials science , plga , composite number , distilled water , controlled release , bioactive glass , apatite , microsphere , drug delivery , biomedical engineering , composite material , chemical engineering , chromatography , nanotechnology , nanoparticle , medicine , chemistry , engineering
Mesoporous bioactive glass (MBG) and composite microspheres with MBG particles embedded in biodegradable poly( D,L ‐lactide‐ co ‐glycolide) (PLGA) matrix have been prepared and used to load gentamicin (GS). The in vitro drug release experiments from both MBG and composite microspheres were conducted in distilled water and phosphate buffered saline (PBS) solution at 37°C for more than 30 days. In both water and PBS, GS release from the MBG was very fast with about 60 wt % of the loaded drug released in the first 24 h, and more than 80 wt % released in two days. MBG/PLGA composite microspheres showed an initial release of about 33 wt % in the first day, and 48 wt % in 2 days, and a subsequent sustained release lasting for more than 4 weeks in PBS. MBG/PLGA composite microspheres may be used as an alternative drug release system, especially as a bone void filler for bone repair due to their combined advantages of sustained release of antibiotics and apatite‐forming ability. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009