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Multinozzle low‐temperature deposition system for construction of gradient tissue engineering scaffolds
Author(s) -
Liu Li,
Xiong Zhuo,
Yan Yongnian,
Zhang Renji,
Wang Xiaohong,
Jin Le
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31176
Subject(s) - materials science , scaffold , gelatin , porosity , tissue engineering , plga , nozzle , polymer , deposition (geology) , composite number , biomedical engineering , composite material , chitosan , nanotechnology , chemical engineering , mechanical engineering , chemistry , engineering , paleontology , biochemistry , sediment , nanoparticle , biology
Tissue engineering is a technology that enables us to construct complicated hominine organs composed of many different types of cells. One of the key points to achieve this goal is to control the material composition and porous structure of the scaffold accurately. A disposable syringe based volume‐driven injecting (VDI) nozzle was proposed and designed to extrude both natural derived and synthetic polymers. A multinozzle low‐temperature deposition and manufacturing (M‐LDM) system is proposed to fabricate scaffolds with heterogeneous materials and gradient hierarchical porous structures. PLGA, collagen, gelatin, chitosan can be extruded without leaking to form hierarchical porous scaffolds for primary study. Composite scaffolds with two kinds of materials were fabricated via two different nozzles to get both hydrophilic and mechanical properties. The results from scanning electron microscopy (SEM) demonstrated that the natural‐derived biomaterials were strongly absorbed onto the synthetic biomaterials to form a stable network. Several gradient PLGA/TCP scaffolds were also fabricated to supply several samples. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009