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Tendon bone healing can be enhanced by demineralized bone matrix: A functional and histological study
Author(s) -
Sundar Siva,
Pendegrass Catherine J.,
Blunn Gordon W.
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31157
Subject(s) - fibrocartilage , demineralized bone matrix , enthesis , tendon , rotator cuff , medicine , dbm , bone healing , surgery , anatomy , articular cartilage , materials science , osteoarthritis , pathology , amplifier , alternative medicine , optoelectronics , cmos
Rotator cuff repair surgery has high failure rates, with tendon reattachment to bone remaining a challenging clinical problem. Increasing the integrity of the healing tendon‐bone interface has been attempted by adopting a number of different augmentation strategies. Because of chondrogenic and osteogenic properties we hypothesise that demineralized bone matrix (DBM) augmentation of a healing tendon‐bone interface will result in improved function, and a morphology that more closely resembles that of a normal enthesis, compared with nonaugmented controls in an ovine patellar tendon model. The right patellar tendon was detached from its insertion and reattached to an osteotomized bone bed using suture anchors. Two groups were analyzed, the control group (without augmentation) and the DBM group (DBM interposed between the tendon and bone). Animals were sacrificed at 12 weeks. Force plate, mechanical, and histomorphometric analyses were performed. Tendon repairs failed at a rate of 33 and 0% for the control and DBM groups, respectively. DBM augmentation resulted in significantly improved functional weight bearing and increased amounts of fibrocartilage and mineralized fibrocartilage. This study shows that DBM enhances tendon‐bone healing and may reduce the high failure rates associated with rotator cuff repair clinically. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009