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Evaluation of substrates for 90° peel adhesion—A collaborative study. II. Transdermal drug delivery systems
Author(s) -
Wokovich Anna M.,
Brown Stanley A.,
Shen Meiyu,
Doub William H.,
Cai Bing,
Sadrieh Nakissa,
Chen Mei Ling,
Machado Stella,
Buhse Lucinda F.
Publication year - 2009
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31149
Subject(s) - transdermal , high density polyethylene , materials science , substrate (aquarium) , biomedical engineering , adhesion , composite material , polyethylene , medicine , pharmacology , oceanography , geology
In a previous study on peel adhesion for medical tapes, it was shown that a stainless steel (SS) substrate better discriminated among medical tapes than a high‐density polyethylene (HDPE) substrate. The objective of this study was to determine if a SS substrate would also better distinguish among transdermal drug delivery systems (TDDSs). Five TDDSs (Vivelle Dot®, Climara®, Catapres‐TTS®, Duragesic®, and Mylan Fentanyl) were evaluated on three different substrates (SS, HDPE, and human cadaver skin). All measurements were made using a dwell time of ∼3 min, a peel angle of 90°, and a peel speed of 300 mm/min. Differences among TDDSs were greater for SS than for HDPE, using the F statistic for testing for differences among TDDSs means as a measure of heterogeneity, thereby indicating greater discrimination by SS. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2009