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Customizing the degradation and load‐bearing profile of 3D polycaprolactone‐tricalcium phosphate scaffolds under enzymatic and hydrolytic conditions
Author(s) -
Yeo Alvin,
Sju Ervi,
Rai Bina,
Teoh Swee Hin
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31145
Subject(s) - polycaprolactone , hydrolytic degradation , hydrolysis , degradation (telecommunications) , load bearing , phosphate , bearing (navigation) , chemistry , enzyme , enzymatic hydrolysis , materials science , chemical engineering , composite material , biochemistry , organic chemistry , computer science , polymer , engineering , telecommunications , artificial intelligence
The degradation of polycaprolactone‐20% tricalcium phosphate (PCL‐TCP) scaffolds was customized for dentoalveolar augmentation applications, where 5–6 months period is optimal. The scaffolds were treated with either 3 M sodium hydroxide (NaOH) or 0.1% lipase solution for a total of 108 h. A greater degree of degradation and reduction in the physical properties of the scaffolds was observed in the lipase treated when compared with NaOH‐treated scaffolds. After 108 h, increases in weight loss and average porosity of the scaffolds in the lipase‐treated group measured 90.6% and 22.9%, respectively, when compared with 52.8% and 11.8% in the NaOH‐treated group. The mechanical testing results revealed a similar trend, with a complete loss of compressive strength and modulus measured as early as 60 h in the lipase‐treated group. The honeycomblike architecture was well preserved throughout the experiment only for the NaOH‐treated scaffolds in addition to a favorable surface roughness ideal for bone‐regeneration applications. In conclusion, pretreatment with NaOH demonstrates a simple approach for tailoring the physical properties and degradation rate of PCL‐TCP scaffolds for the potential use as biomaterials targeted for dentoalveolar bone‐regeneration procedures. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008