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New polymer for intra‐abdominal meshes—PVDF copolymer
Author(s) -
Conze Joachim,
Junge Karsten,
Weiß Claudia,
Anurov Michael,
Oettinger Alexander,
Klinge Uwe,
Schumpelick V.
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31106
Subject(s) - polygon mesh , shrinkage , materials science , adhesion , polyvinylidene fluoride , biomedical engineering , adhesive , copolymer , polypropylene , polymer , composite material , medicine , mathematics , geometry , layer (electronics)
Purpose: Full tissue integration without adhesion formation is still a challenge for intra‐abdominal mesh materials. Purpose of this study was to investigate the adhesive potential and fibrocollagenous ingrowth of a polymer blend of polyvinylidene fluoride and hexafluorpropylene (co‐PVDF), an established suture material in vascular surgery, when placed as a mesh in the intra‐abdominal position. The results were compared with a matching polypropylene (PP) mesh. Methods: In an established rabbit model, mesh implantation was performed by laparoscopy in the intraperitoneal onlay mesh technique. After 7, 21, and 90 days the degree of adhesion formation, foreign body reaction, bridging, and shrinkage of mesh area were investigated. Results: In the early phase after 7 and 21 days we found significantly more adhesions for PP, but no differences after 90 days. Analysis of tissue reaction showed a significantly lower fibrotic reaction for co‐PVDF. The degree of shrinkage revealed no significant difference. Conclusion: Large‐pore PP and co‐PVDF‐meshes showed comparable good results in the intra‐abdominal position, with a reduced inflammatory tissue reaction for co‐PVDF. Large pore meshes should be considered an alternative for the development of intraperitoneal onlay meshes. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008