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Three‐layered membranes of collagen/hydroxyapatite and chitosan for guided bone regeneration
Author(s) -
Teng ShuHua,
Lee EunJung,
Wang Peng,
Shin DuSik,
Kim HyounEe
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31082
Subject(s) - membrane , chitosan , materials science , ultimate tensile strength , slurry , composite number , layer (electronics) , regeneration (biology) , filtration (mathematics) , composite material , chemical engineering , morphology (biology) , biomedical engineering , chemistry , biochemistry , mathematics , genetics , medicine , statistics , engineering , biology , microbiology and biotechnology
The purpose of this study was to design a novel hybrid membrane with optimized properties for guided bone regeneration (GBR). Both the top and bottom layers of the sandwich‐structured membrane were composed of collagen containing 20 wt% hydroxyapatite (HA), while the middle layer was made of chitosan. The above three layers were formulated into an integral membrane from their respective slurries through a layer‐by‐layer filtration process. The phase and composition of the membrane were confirmed by FT‐IR and XRD analyses. The observation of its morphology by SEM showed that the membrane had a porous structure and structural integrity. The chitosan layer ensured the high tensile strength and elastic modulus of the membrane, while the presence of the collagen/HA composite layers endowed it with good flexibility and bioactivity. These results suggest that the integrated membrane prepared in this study would have the potential for use as a GBR material. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008