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Sol–gel processed porous silica carriers for the controlled release of diclofenac diethylamine
Author(s) -
Czarnobaj Katarzyna,
Czarnobaj Joanna
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31076
Subject(s) - diethylamine , diclofenac , hydrolysis , materials science , sol gel , chemical engineering , silica gel , porosity , chemistry , chromatography , organic chemistry , nanotechnology , composite material , biochemistry , engineering
Silica xerogels doped with diclofenac diethylamine were prepared by the sol–gel method from a hydrolysed tetraethoxysilane (TEOS) solution containing diclofenac diethylamine. Two different catalysts, drying conditions and levels of water content were used to alter the microstructure of the silica xerogels. The aim of this study was to determine the rate of Diclofenac release from the silica xerogels. This in vitro study showed that the sol–gel method is useful for entrapping Diclofenac in the pores of xerogels. It also showed that, in vitro , Diclofenac is released from the silica xerogel, through the pores, by diffusion. Base‐catalysed gels proved to be much more effective than acid‐catalyzed gels. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008