Premium
Hybrid coating of hydroxyapatite and collagen within poly( D,L ‐lactic‐ co ‐glycolic acid) scaffold
Author(s) -
Li Jiashen,
Yuan Xiaoyan,
He Fei,
Mak Arthur F. T.
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31031
Subject(s) - plga , glycolic acid , coating , scaffold , materials science , polymer , composite number , chemical engineering , biodegradable polymer , lactic acid , composite material , microsphere , biomedical engineering , nanotechnology , nanoparticle , medicine , engineering , biology , bacteria , genetics
To improve the cell‐affinity of biodegradable polymer scaffold, coating hydroxyapatite (HA) or collagen on the surface of polymer materials seemed to be a strategy to combine both advantages of them. The objective of this study was to develop a novel method to introduce HA and collagen inside polymer scaffold uniformly. HA and collagen suspension was mixed with paraffin microspheres, and molded to form a composite sample. After the sample was dried, HA/collagen composite was left among and on the surface of paraffin microspheres. Poly( D,L ‐lactic‐ co ‐glycolic acid) (PLGA) (50/50) solution was cast into the inter‐space of the paraffin microspheres and dried. Afterwards, the paraffin was dissolved and removed, HA/collagen was transferred to the surface and even inside of the pore wall of PLGA scaffolds. Collagen fibers and HA particles which were inlaid inside the PLGA pore wall could help to enhance the coating strength between HA/Col coating and the pore wall surface of the PLGA scaffold. The scaffolds with HA/Col coating were expected to exhibit desirable properties in bone tissue engineering. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008