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In vivo response of porous hydroxyapatite and β‐tricalcium phosphate prepared by aqueous solution combustion method and comparison with bioglass scaffolds
Author(s) -
Ghosh Samir K.,
Nandi Samit K.,
Kundu Biswanath,
Datta Someswar,
De Dipak K.,
Roy Sujit K.,
Basu Debabrata
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.31009
Subject(s) - bioceramic , materials science , biomaterial , apatite , aqueous solution , porosity , calcium , in vivo , scanning electron microscope , phosphate , chemical engineering , biomedical engineering , composite material , nuclear chemistry , chemistry , mineralogy , nanotechnology , metallurgy , medicine , microbiology and biotechnology , organic chemistry , engineering , biology
Pure hydroxyapatite (HAp) and a biphasic calcium phosphate [containing 90% of β‐tri‐calcium phosphate (β‐TCP) and 10% HAp] were tailored through an aqueous solution combustion synthesis. Porous struts were prepared using all the powders along with bioglass, a known bioactive material, and subsequently characterized. Sterilized struts were implanted to the lateral side of radius bone of 24 black Bengal goats of either sex, in which a blank hole was left unfilled in a group of six specimens to act as control. The bone formation response of the three implanting materials in vivo has been studied using scanning electron microscope and histological analysis in contrast with positive controls. Push‐out tests were used to assess the mechanical strength at the bone–biomaterial interface. It was observed that interfacial response was strongly dependent on combinations of different physical and chemical parameters. The surface of β‐TCP exhibited similar characteristics of bone and was distinct from those of intervening apatite layer of bioglass. Lower bone ingrowth and reduced strength was observed with HAp compared to β‐TCP/bioglass‐based implants. Bone formation response of the Ca‐P material varied according to the composition of the implanting material, which could be tailored through this novel synthesis. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008