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A facile method to construct hybrid multilayered films as a strong and multifunctional antibacterial coating
Author(s) -
Yuan Weiyong,
Ji Jian,
Fu Jinhong,
Shen Jiacong
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30979
Subject(s) - construct (python library) , coating , materials science , nanotechnology , computer science , programming language
A multifunctional multilayered film containing TiO 2 nanoparticles as contact‐active antibacterial agent and nanosilver as a release‐active antibacterial agent was fabricated via layer‐by‐layer assembly. TiO 2 nanoparticles with the anatase crystalline dominant structure were synthesized via a sol‐gel method. The QCM, AFM, and contact angle measurement results indicated that the TiO 2 nanoparticle‐chitosan was successfully assembled with heparin via layer‐by‐layer assembly. The UV visible spectroscopy demonstrated that the silver ions could be loaded into the multilayers and in situ synthesize silver nanoparticles in the multilayers template. The short‐term antibacterial assay showed the TiO 2 ‐chitosan/heparin multilayers loaded with nanosilver was bactericidal both in the low intensity UV light and in the dark. The long‐term antibacterial assay indicated although the antibacterial in dark decreased with the PBS immersion time, the hybrid multilayered films sustained the long‐term antibacterial in the low intensity UV light. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008