Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications | Zendy

Jones David S. | Zendy; Lorimer Colin P. | Zendy; McCoy Colin P. | Zendy; Gorman Sean P. | Zendy

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Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications

Author(s) -

Jones David S.,

Lorimer Colin P.,

McCoy Colin P.,

Gorman Sean P.

Publication year - 2008

Publication title -

journal of biomedical materials research part b: applied biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.665

H-Index - 108

eISSN - 1552-4981

pISSN - 1552-4973

DOI - 10.1002/jbm.b.30960

Subject(s) - lower critical solution temperature , self healing hydrogels , materials science , methacrylate , (hydroxyethyl)methacrylate , contact angle , polymer chemistry , copolymer , swelling , polymer , chemical engineering , composite material , engineering

In this study, a series of hydrogels was synthesized by free radical polymerization, namely poly(2‐(hydroxyethyl)methacrylate) (pHEMA), poly(4‐(hydroxybutyl)methacrylate) (pHBMA), poly(6‐(hydroxyhexyl)methacrylate) (pHHMA), and copolymers composed of N ‐isopropylacrylamide (NIPAA), methacrylic acid (MA), NIPAA, and the above monomers. The surface, mechanical, and swelling properties (at 20 and 37°C, pH 6) of the polymers were determined using dynamic contact angle analysis, tensile analysis, and thermogravimetry, respectively. The T g and lower critical solution temperatures (LCST) were determined using modulated DSC and oscillatory rheometry, respectively. Drug loading of the hydrogels with chlorhexidine diacetate was performed by immersion in a drug solution at 20°C (

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