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Characterization of the physicochemical, antimicrobial, and drug release properties of thermoresponsive hydrogel copolymers designed for medical device applications
Author(s) -
Jones David S.,
Lorimer Colin P.,
McCoy Colin P.,
Gorman Sean P.
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30960
Subject(s) - lower critical solution temperature , self healing hydrogels , materials science , methacrylate , (hydroxyethyl)methacrylate , contact angle , polymer chemistry , copolymer , swelling , polymer , chemical engineering , composite material , engineering
In this study, a series of hydrogels was synthesized by free radical polymerization, namely poly(2‐(hydroxyethyl)methacrylate) (pHEMA), poly(4‐(hydroxybutyl)methacrylate) (pHBMA), poly(6‐(hydroxyhexyl)methacrylate) (pHHMA), and copolymers composed of N ‐isopropylacrylamide (NIPAA), methacrylic acid (MA), NIPAA, and the above monomers. The surface, mechanical, and swelling properties (at 20 and 37°C, pH 6) of the polymers were determined using dynamic contact angle analysis, tensile analysis, and thermogravimetry, respectively. The T g and lower critical solution temperatures (LCST) were determined using modulated DSC and oscillatory rheometry, respectively. Drug loading of the hydrogels with chlorhexidine diacetate was performed by immersion in a drug solution at 20°C (