Premium
Use of a chitosan‐based hemostatic dressing in laparoscopic partial nephrectomy
Author(s) -
Xie Hua,
Khajanchee Yashodhan S.,
Teach Jeffrey S.,
Shaffer Brian S.
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30946
Subject(s) - hemostasis , medicine , surgery , nephrectomy , chitosan , hemostatic agent , blood loss , bandage , wedge resection , kidney , resection , biochemistry , chemistry
Objectives: An external chitosan‐based hemostatic bandage has been used to control aggressive bleeding from traumatic injuries. This study was to evaluate the feasibility of using an internal chitosan dressing based on the external platform to control hemorrhage and urinary leakage by sealing off the parenchymal wound following Laparoscopic partial nephrectomy (LPN) in a porcine model. Methods: Nine heparinized domestic swine underwent bilateral laparoscopic partial nephrectomies involving either a polar ( N = 13) or wedge resection ( N = 5) followed by treatment with the chitosan dressing. Estimated blood loss, hemostatic score, urinary leakage, operative time, and adhesion score of the chitosan dressing were recorded. Results: Of the 18 procedures, 17 achieved complete hemostasis after deployment of the chitosan dressing. The hemostasis score improved significantly after the deployment in both polar ( p < 0.001) and wedge ( p = 0.017) resections. The rate of successful pyelocaliceal sealing was 85% (11/13) in polar resections and 60% (3/5) in wedge resections. Conclusion: The chitosan‐based hemostatic dressing is effective as a primary or supplemental material for controlling parenchymal hemorrhage and sealing the renal collecting system following LPN in the animal model. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008