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Histological and histomorphometric investigations on bone integration of rapidly resorbable calcium phosphate ceramics
Author(s) -
Bernstein Anke,
Nöbel Doreen,
Mayr Hermann O.,
Berger Georg,
Gildenhaar Renate,
Brandt Jörg
Publication year - 2008
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30891
Subject(s) - coating , materials science , connective tissue , ceramic , biomedical engineering , calcium , bone tissue , mineralization (soil science) , implant , bone formation , dentistry , chemistry , composite material , metallurgy , medicine , surgery , pathology , organic chemistry , nitrogen , endocrinology
Resorbable ceramics can promote the bony integration of implants. Their rate of degradation should ideally be synchronized with bone regeneration. We report here the results of a histological study of implants with two resorbable calcium phosphate ceramic coatings: Ca 2 KNa(PO 4 ) 2 ‐(GB14) and Ca 10 [K/Na](PO 4 ) 7 ‐(602020). The results attained with these ceramic‐coated implants show the benefits of these materials with regard to bioactive bone‐healing stimulation, compared with uncoated implants. The GB14 ceramic coating exhibited greater bone regeneration and differentiation on its surface than the conventional hydroxyapatite coating and helped bone tissue achieve more extensive contact free of connective tissue. Not until the coating disintegrated did the histological features of GB14‐ and 602020‐coated implants converge‐both implant types were integrated into bone. Rapid disintegration of the coating material, as with 602020, supports osteoblast proliferation but has negative effects on bone mineralization. Both resorbable ceramics tested, GB14 and 602020, demonstrated bioactivity; even metal surfaces coated with these materials were populated by mature bone tissue without connective tissue after disintegration of their ceramic coating. The less rapidly degrading material, GB14, achieved better results. Degradable calcium phosphate coatings have the potential to stimulate bone regeneration. From the histological viewpoint, the resorbable ceramics examined here can be recommended as coating materials for clinical use. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008