z-logo
Premium
Acrylic injectable and self‐curing formulations for the local release of bisphosphonates in bone tissue
Author(s) -
RodríguezLorenzo L. M.,
Fernández M.,
Parra J.,
Vázquez B.,
LópezBravo A.,
Román J. San
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30833
Subject(s) - curing (chemistry) , dentistry , bone tissue , biomedical engineering , medicine , materials science , composite material
Two bisphosphonates (BPs), namely 1‐hydroxy‐2‐[4‐aminophenyl]ethane‐1,1‐diphosphonic acid (APBP) and 1‐hydroxy‐2‐[3‐indolyl]ethane‐1,1‐diphosphonic acid (IBP), have been synthesized and incorporated to acrylic injectable and self‐curing formulations. Alendronic acid monosodium trihydrated salt (ALN) containing cement was formulated as control. These systems have potential applications in low density hard tissues affected by ailments characterized by a high osteoclastic resorption, i.e. osteoporosis and osteolysis. Values of curing parameters of APBP and IBP were acceptable to obtain pastes with enough fluency to be injected through a biopsy needle into the bone cavity. Working times ranged between 8 and 15 min and maximum temperature was around 50°C. Cured systems stored for a month in synthetic body fluid had compressive strengths between 90 and 96 MPa and modulus between 1.2 and 1.3 GPa, which suggest mechanical stabilization after setting and in the short time. BPs were released in PBS at an initial rate depending on the corresponding chemical structure in the order ALN > APBP > IBP to give final concentrations in PBS of 2.21, 0.44, and 0.19 mol/mL for ALN, APBP, and IBP, respectively. Cytotoxicities of bisphosphonates were evaluated, IC 50 values being in the order APBP > ALN > IBP. Absence of cytotoxicity coming from leachables of the cured systems was observed in all cases independently of the BP. An improved cell growth and proliferation for the systems loaded with APBP and IBP compared with that loaded with ALN was observed, as assessed by measuring cell adhesion and proliferation, and total DNA content. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here