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Synthesis and characterization of radiopaque magnetic core‐shell nanoparticles for X‐ray imaging applications
Author(s) -
Galperin Anna,
Margel Shlomo
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30821
Subject(s) - maghemite , materials science , nanoparticle , magnetic resonance imaging , characterization (materials science) , shell (structure) , magnetic nanoparticles , core (optical fiber) , dextran , polymer , polymerization , nuclear magnetic resonance , emulsion polymerization , chemical engineering , nanotechnology , composite material , chemistry , radiology , chromatography , medicine , physics , engineering
Radiopaque magnetic γ‐Fe 2 O 3 /poly(2‐methacryloyloxyethyl(2,3,5‐triiodobenzoate)) core‐shell nanoparticles of narrow size distribution were prepared by emulsion polymerization of the iodinated monomer 2‐methacryloyloxyethyl(2,3,5‐triiodobenzoate) in the presence of maghemite (γ‐Fe 2 O 3 nanoparticles coated with a dextran shell are commonly used as contrast agents for magnetic resonance imaging (MRI). The present nanoparticles have similar core‐shell structure substituting the dextran for the iodo polymer. These core‐shell nanoparticles may therefore be useful as imaging contrast agents to detect various pathogenic zones and to observe different disease states in both modes: X‐ray and MRI. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007