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Development of self‐expandable covered stents
Author(s) -
Sato Sachiko,
Nakayama Yasuhide,
Miura Yoshihiro,
Okamoto Yoshihiro,
Asano Hiroyuki,
IshibashiUeda Hatsue,
Zhou YueMin,
Hayashida Kyoko,
Matsuhashi Toshio,
Seiji Kazumasa,
Sato Akihiro,
Yamada Takayuki,
Takahashi Shoki,
Ishibashi Tadashi
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30802
Subject(s) - materials science , biomedical engineering , stent , coating , microporous material , composite material , surgery , medicine
We newly developed self‐expandable covered stents by combining two of our original technologies. Of these, the first is the dip‐coating covering method that was developed previously for balloon‐expandable stents; the other is the newly developed self‐expandable Nitinol stents, namely, Sendai stents. The three types of covered stents with the expansion diameter of 4.5, 5.0, or 6.0 mm thus obtained had a laser‐processed microporous elastomeric cover film (pore diameter: 100 μm, interpore distance: 250 μm). Although the film was extremely thin (∼15 μm), the film could be expanded without causing any damage, the strut was completely embedded within the film, and the luminal surface of the film was smooth and flat. Mechanical properties such as ideal flexibility to follow the shapes of arteries were almost retained even after covering. As appropriate drugs, the blood‐contacting inner and tissue‐contacting outer surfaces of the film were differentially coated with argatroban for antithrombogenicity or FK506 for anti‐inflammation, respectively. The preliminary in vivo study indicated that the covered stents mounted in the delivery catheter were navigated and placed to appropriate position in the arteries, and permissible neointimal thickening after 1‐month implantation was observed similarly in noncovered stents. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007

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