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Fibroblastic interactions with high‐porosity Ti‐6Al‐4V metal foam
Author(s) -
Cheung Serene,
Gauthier Maxime,
Lefebvre LouisPhilippe,
Dunbar Michael,
Filiaggi Mark
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30749
Subject(s) - porosity , materials science , metal foam , fibroblast , scaffold , cell growth , composite material , bridging (networking) , cell culture , biomedical engineering , chemistry , medicine , computer network , biochemistry , biology , computer science , genetics
A novel metallic Ti‐6Al‐4V foam in development at the National Research Council of Canada was investigated for its ability to foster cell attachment and growth using a fibroblast cell culture model. The foam was manufactured via a powder metallurgical process that could produce interconnected porosity greater than 70%. Cell attachment was assessed after 6 and 24 h, while proliferation was examined after 3 and 7 days. Ingrown fibroblasts displayed a number of different morphologies; some fibroblasts were spread thinly in close apposition with the irregular surface, or more often had several anchorage points and extended in three dimensions as they spanned pore space. It was also demonstrated that fibroblasts were actively migrating through the porous scaffold over a 14‐day period. In a 60‐day extended culture, fibroblasts were bridging and filling macropores and had extensively infiltrated the foams. Overall, it was established that this foam was supportive of cell attachment and proliferation, migration through the porous network, and that it was capable of sustaining a large cell population. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007