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Polymer scaffolds with interconnected spherical pores and controlled architecture for tissue engineering: Fabrication, mechanical properties, and finite element modeling
Author(s) -
Diego Raúl Brígido,
Estellés Jorge Más,
Sanz José Antonio,
GarcíaAznar José Manuel,
Sánchez Manuel Salmerón
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30683
Subject(s) - materials science , finite element method , porosity , composite material , compression (physics) , scanning electron microscope , elastic modulus , fabrication , modulus , interconnection , stress (linguistics) , scaffold , biomedical engineering , structural engineering , engineering , telecommunications , medicine , linguistics , philosophy , alternative medicine , pathology
A method is proposed in which the geometric properties of 3D scaffolds with application in tissue engineering can be tailored: porosity, pore size, and interconnection throat size. The architecture of the fabricated scaffolds is analyzed by scanning electron microscopy. The mechanical properties of these structures are discussed on the basis of compression stress–strain measurements. Moreover, the mechanical properties of the scaffolds are estimated by means of finite element modeling (FEM) in which the compression stress–strain test is simulated on an ideal structure based on the crystalline face centered cubic system. The elastic properties of the constructs are explained on the basis of the FEM model that supports the main mechanical conclusion of the experimental results: the compressive modulus in the first linear region does not depend on the geometric characteristics of the pore (pore size, interconnection throat size) but only on the total porosity of the scaffold. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006