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Characterization and in vivo evaluation of sol–gel derived hydroxyapatite coatings on Ti6Al4V substrates
Author(s) -
Balamurugan A.,
Rebelo A.,
Kannan S.,
Ferreira J.M.F.,
Michel J.,
Balossier G.,
Rajeswari S.
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30682
Subject(s) - materials science , biocompatibility , titanium , titanium alloy , coating , implant , sol gel , sintering , biomedical engineering , alloy , composite material , metallurgy , nanotechnology , surgery , medicine
Hydroxyapatite (HAP) based coatings on titanium alloy Ti6Al4V were attempted by sol–gel process. Precursor sol was dip‐coated onto the substrates and the formation of HAP as the main phase was ensured after the sintering of coatings at 900°C, as confirmed by the characterization studies involving XRD, FT‐IR, Raman, and SEM‐EDXS analysis. The biocompatibility of HAP‐based coated titanium implants was tested by implantation studies in rabbit's tibia for a period of 8 weeks. Bone remodelling and inflammatory responses of the implants were studied during the implantation period. The better tissue–implant interaction of the coated implants with respect to the uncoated implants was observed after a defect healing period of 8 weeks. A coated implant with no evidence of rejection is a further advantage of the sol–gel derived HAP coating. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006