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Radiation synthesis of poly(ethylene glycol)/acrylic acid hydrogel as carrier for site specific drug delivery
Author(s) -
Ali Amr ElHag,
Hegazy ElSayed A.
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30650
Subject(s) - swelling , self healing hydrogels , materials science , ethylene glycol , ionic strength , acrylic acid , peg ratio , copolymer , ketoprofen , polymer chemistry , chemical engineering , ionic bonding , drug delivery , diffusion , aqueous solution , kinetics , drug carrier , nuclear chemistry , polymer , composite material , organic chemistry , chromatography , chemistry , nanotechnology , ion , engineering , quantum mechanics , thermodynamics , physics , finance , economics
pH‐sensitive hydrogels were prepared from poly(ethylene glycol) (PEG) and acrylic acid (AAc) in aqueous solution employing γ‐radiation‐induced copolymerization and crosslinking. The swelling behavior of the prepared hydrogels was determined by investigating the time and pH‐dependent swelling of the (PEG/AAc) hydrogels of different PEG content. The effect of environmental parameters such as pH and ionic strength on the swelling kinetics was studied. The results not only show the dependence of the swelling indices on the pH value of the swelling medium but also show a clear dependence of the diffusion coefficient on the ionic strength of the medium. To estimate the ability of the prepared copolymer to be used as a colon‐specific drug carrier, the release of ketoprofen was studied as a function of time at pH 1 and pH 7. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006