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In vitro characterization of a calcium sulfate/PLLA composite for use as a bone graft material
Author(s) -
Mamidwar Sachin S.,
Arena Christopher,
Kelly Shawn,
Alexander Harold,
Ricci John
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30636
Subject(s) - pellets , dissolution , coating , materials science , simulated body fluid , composite number , scanning electron microscope , composite material , electron microprobe , nuclear chemistry , chemical engineering , metallurgy , chemistry , engineering
A study was conducted to characterize the dissolution, morphology, and chemical composition of a calcium sulfate/poly ( L ‐lactic acid) (CS/PLLA) composite material before and after immersion in simulated body fluid (SBF). Twelve groups of experimental samples were prepared by coating CS pellets 1, 2, 3, or 4 times with one of three concentrations of a PLLA solution and wrapping them in mesh; CS pellets for use as controls were similarly prepared but not coated. The PLLA coating added from 1 to 22% to the weight of experimental pellets; scanning electron microscopy revealed that the coating thickness ranged from 2 to 50 μm depending on the concentration of the coating solution and the number of coatings. All samples were immersed in SBF for up to 97 days. After immersion, the experimental coatings thinned out, small cracks and holes formed in the coating, and the coating became roughened. Mean dissolution rates for each of the 12 CS/PLLA groups were significantly lower than those of uncoated CS pellets; among CS/PLLA groups, dissolution rates varied according to concentration of the coating solution and number of coatings. The half‐life of pure CS pellets was 19 days whereas the half‐life of CS/PLLA composite pellets ranged from 30 to 70 days. X‐ray microprobe analysis of experimental pellets after immersion in SBF revealed that mineralization occurred in the CS portion of these pellets as well as on the coating; most of the mineral was calcium phosphate, most of which was on the coating. Further studies will be required to confirm this composite's promise as a clinically effective osteoconductive material. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006