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Biocompatibility of a new radiopaque iodine‐containing acrylic bone cement
Author(s) -
van HooyCorstjens Catharina S. J.,
Bulstra Sjoerd K.,
Knetsch Menno L. W.,
Geusens Piet,
Kuijer Roel,
Koole Leo H.
Publication year - 2007
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30602
Subject(s) - radiodensity , biocompatibility , cement , materials science , bone cement , biocompatible material , barium sulfate , biomedical engineering , dentistry , composite material , medicine , surgery , radiography , metallurgy
Radiopacity in the vast majority of the commercially available acrylic bone cements that are used clinically is provided by particles of either BaSO 4 or ZrO 2 . Literature reports have shown these agents to have a detrimental effect on some mechanical properties of the cements as well as on its biological response. We, therefore, have developed a new type of bone cement, for which radiopacity results from the presence of an iodine‐containing methacrylic copolymer. The focus of the present work was the comparison of the biocompatibility of this new cement and a commercially available cement that contains barium sulfate. In vitro experiments show that both cements are cytocompatible materials, for which no toxic leachables are found. Implantation of the cements in a rabbit for three months resulted in the occasional presence of a thin fibrous tissue at the cement–bone interface, which is common for acrylic bone cements. Consideration of all the results led to the conclusion that the new cement is as biocompatible as the BaSO 4 ‐containing one. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2007