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Modulation of protein release from biodegradable core–shell structured fibers prepared by coaxial electrospinning
Author(s) -
Jiang Hongliang,
Hu Yingqian,
Zhao Pengcheng,
Li Yan,
Zhu Kangjie
Publication year - 2006
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30510
Subject(s) - ethylene glycol , materials science , electrospinning , bovine serum albumin , scanning electron microscope , peg ratio , fiber , shell (structure) , coaxial , core (optical fiber) , controlled release , chemical engineering , composite material , morphology (biology) , polymer chemistry , chemistry , polymer , nanotechnology , chromatography , biology , genetics , electrical engineering , finance , engineering , economics
Biodegradable core–shell structured fibers with poly(ε‐caprolactone) as shell and bovine serum albumin (BSA)‐containing dextran as core were prepared by coaxial electrospinning for incorporation and controlled release of proteins. BSA loading percent in the fibers and its release rate could be conveniently varied by the feed rate of the inner dope during electrospinning. With the increase in the feed rate of the inner dope, there was an associated increase in the loading percent and accelerated release of BSA. Poly(ethylene glycol) (PEG) was added to the shell section of the fibers to further finely modulate the release behavior of BSA. It was revealed that the release rate of BSA increased with the PEG percent in the shell section. By varying the feed rate of the inner dope and PEG content, most of BSA could be released from the core–shell structured fibers within the period of time ranging from 1 week to more than 1 month. The effect of the feed rate of the inner dope and addition of PEG into the shell section on the fiber morphology was also examined by scanning electron microscope. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006