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An improved hydrophilicity via electrospinning for enhanced cell attachment and proliferation
Author(s) -
Kim Chi Hun,
Khil Myung Seob,
Kim Hak Yong,
Lee Hyun Uk,
Jahng Kwang Yeop
Publication year - 2006
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30484
Subject(s) - electrospinning , thermogravimetric analysis , vinyl alcohol , contact angle , materials science , scanning electron microscope , chemical engineering , wetting , polymer chemistry , composite material , polymer , engineering
The wettability of electrospun poly(ϵ‐caprolactone) (PCL) mats was improved by co‐electrospinning with poly(vinyl alcohol) (PVA), by double‐spinneret electrospinning method. The improved hydrophilicity of the hybrid PCL/PVA mats was confirmed by water contact angle measurement. The in vitro cell attachment on the hydrophobic PCL and hydrophilically modified PCL/PVA mats was compared by culture studies using human prostate epithelial cells (HPECs). The stability of water‐soluble PVA component in the electrospun PCL/PVA mats was checked by thermogravimetric analysis and intensity of fluorescence material after immersion in water for 7 days. The images from scanning electron microscopy, field emission scanning electron microscopy, and optical microscopy showed that the attachment and proliferation rate of HPECs were improved by introducing PVA into the electrospun PCL mats. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006