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Calcium phosphate cement reinforced by polypeptide copolymers
Author(s) -
Lin Jiaping,
Zhang Suning,
Chen Tao,
Liu Changshen,
Lin Shaoliang,
Tian Xiaohui
Publication year - 2006
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30392
Subject(s) - copolymer , materials science , micelle , composite material , scanning electron microscope , calcium , phosphate , morphology (biology) , polymer chemistry , polymer , organic chemistry , aqueous solution , chemistry , biology , metallurgy , genetics
Water‐based calcium phosphate with bone repairing capability was reinforced by polypeptide graft copolymers and micelles that were formed by polypeptide copolymers. The mechanical studies showed that the compression strength and fracture energy of the calcium phosphate cement (CPC)/polypeptide composites are appreciably higher than those of CPC. The molecular structure of the polypeptide graft copolymers and the association form of the polypeptide copolymers exhibit a marked effect on the mechanical properties of CPC/polypeptide composites. The polypeptide copolymers with more hydrophilic side chains and with core‐shell micelle forms have more effective reinforcement effect. The morphological studies based on the scanning electron microscope (SEM) observations revealed that both polypeptide graft copolymers and polypeptide copolymer micelles are well dispersed in CPC matrix. According to the obtained experimental results, reinforcement mechanism was suggested. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006