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PLA stereocopolymers as sources of bioresorbable stents: Preliminary investigation in rabbit
Author(s) -
Lafont Antoine,
Li Suming,
Garreau Henri,
Cornhill Frederic,
Vert Michel
Publication year - 2006
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30391
Subject(s) - rabbit (cipher) , in vivo , osteosynthesis , stent , biomedical engineering , artery , materials science , surgery , medicine , computer science , biology , computer security , microbiology and biotechnology
The aim of the present work was to evaluate whether the degradation of PLA‐based bioresorbable stents can be modulated via the configuration of repeating units as it is the case in other applications like osteosynthesis. The first obstacle was finding a stent design that could allow implantation in the aorta of a rabbit taken as a model of a human coronary artery. In the absence of guidelines other than those tentatively proposed in patents, several simple designs were considered that allowed us to evaluate the fate of the stents made of poly(lactic acid) stereocopolymers with L /( L + D ) ratio of 0.92 (PLA 92 ) and 0.50 (PLA 50 ) up to 6 months post in vivo implantation. Our findings show the feasibility of bioresorbable stenting using PLA stereocopolymers and that PLA 50 degraded faster than PLA 92 . Therefore, using stereocopolymers appears as a means to vary the degradation rate and adapt it to the artery remodelling process that is very much dependent on the release of the stenting stress protection. © 2006 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006