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Periodontal growth factors and tissue carriers: Biocompatibility and mitogenic efficacy in vitro
Author(s) -
Cesari Claudio,
Gatto Maria Rosaria,
Malucelli Francesco,
Raspanti Mario,
Zucchelli Giovanni,
Checchi Luigi
Publication year - 2006
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30337
Subject(s) - biocompatibility , platelet derived growth factor receptor , growth factor , platelet derived growth factor , in vitro , periodontal fiber , cell growth , biomedical engineering , transforming growth factor , chemistry , pharmacology , materials science , microbiology and biotechnology , medicine , biology , dentistry , biochemistry , receptor , organic chemistry
Clinical research has long been testing techniques of integrating biomaterials with many external factors, such as simple proteins or more complicated devices, in order to achieve the restitutio ad integrum of periodontium . This study assessed the in vitro effectiveness of platelet derivate growth factor‐BB (PDGF) and insulin growth factor I (IGF); the biocompatibility of materials like Paroguide, Oclastim membranes, Gingistat sponges, Surgiplaster, and Capset; and their efficacy as carriers for the platelet derivate growth factor‐BB (PDGF) and insulin growth factor I (IGF). Fibroblasts from the human periodontal ligament were incubated with growth factors free or vehiculated. Mitogenic effect was evaluated by measuring the growth rate and biocompatibility by observing cell morphology at SEM. PDGF was the most effective in stimulating cell proliferation both in solution ( p < 0.001) and vehiculated ( p < 0.01). Surgiplaster and Capset were more biocompatible; however, final analysis to assess their efficacy as carriers failed to disclose significant differences between experimental findings and control. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2006