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The preparation and characteristics of a carbonated hydroxyapatite/collagen composite at room temperature
Author(s) -
Liao Susan,
Watari Fumio,
Uo Motohiro,
Ohkawa Shoji,
Tamura Kazuchika,
Wang Wei,
Cui Fuzhai
Publication year - 2005
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30315
Subject(s) - crystallinity , composite number , thermogravimetric analysis , microstructure , materials science , transmission electron microscopy , fiber , composite material , chemical engineering , collagen fiber , bone tissue , nanotechnology , biomedical engineering , anatomy , medicine , engineering
Nanocarbonated hydroxyapatite/collagen (nCHAC) composite was prepared at room temperature via biomimetic self‐assembly method. X‐ray diffraction (XRD), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM) were performed. This composite shows the same inorganic phase of natural bone with nanosized level and low degree of crystallinity, and contains 2.8–14.7 wt % of carbonated content. TEM results confirm that the microstructure of this composite is the mineralized collagen fiber bundle like the hierarchical structure of natural bone. The diameter of a single mineralized collagen fiber is about 4 nm. Slightly different assembly units of the composite with different carbonates and collagen were demonstrated. The carbonated percentage affects the mineral crystal size and collagen fibril assembly. Because of the biomimetic component and microstructure, the use of nCHAC composite is promising for hard tissue therapy. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2005