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Stability and effectiveness against bacterial adhesion of poly(ethylene oxide) coatings in biological fluids
Author(s) -
Roosjen Astrid,
de Vries Joop,
van der Mei Henny C.,
Norde Willem,
Busscher Henk J.
Publication year - 2005
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30227
Subject(s) - adhesion , ethylene oxide , materials science , contact angle , staphylococcus epidermidis , biomaterial , saliva , ethylene glycol , oxide , chemical engineering , chemistry , composite material , nanotechnology , bacteria , organic chemistry , biochemistry , biology , metallurgy , engineering , copolymer , genetics , staphylococcus aureus , polymer
Poly(ethylene oxide) (PEO) coatings have been shown to reduce the adhesion of different microbial strains and species and thus are promising as coatings to prevent biomaterial‐centered infection of medical implants. Clinically, however, PEO coatings are not yet applied, as little is known about their stability and effectiveness in biological fluids. In this study, PEO coatings coupled to a glass substratum through silyl ether bonds were exposed for different time intervals to saliva, urine, or phosphate‐buffered saline (PBS) as a reference at 37°C. After exposure, the effectiveness of the coatings against bacterial adhesion was assessed in a parallel plate flow chamber. The coatings appeared effective against Staphylococcus epidermidis adhesion for 24, 48, and 0.5 h in PBS, urine, and saliva, respectively. Using XPS and contact‐angle measurements, the variations in effectiveness could be attributed to conditioning film formation. The overall short stability results from hydrolysis of the coupling of the PEO chains to the substratum. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater

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