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Novel polyelectrolyte carboxymethyl konjac glucomannan–chitosan nanoparticles for drug delivery. II. Release of albumin in vitro
Author(s) -
Du Jian,
Zhang Sheng,
Sun Rui,
Zhang LiFang,
Xiong ChengDong,
Peng YuXing
Publication year - 2004
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30156
Subject(s) - chitosan , polyelectrolyte , drug delivery , chemistry , in vitro , drug , glucomannan , nanoparticle , albumin , chemical engineering , pharmacology , nanotechnology , materials science , biochemistry , organic chemistry , polymer , medicine , engineering
Carboxymethyl konjac glucomannan–chitosan (CKGM‐CS) nanoparticles were spontaneously prepared under very mild conditions via polyelectrolyte complexation. Bovine serum albumin (BSA), as a model protein drug, was incorporated into the CKGM‐CS nanoparticles. The physicochemical properties of the BSA‐loaded nanoparticles were identified by Zetasizer 3000 and FTIR spectrophotometry. Their sizes were from 330 nm to 900 nm; zeta potentials were positive according to varies CKGM/CS ratios. The encapsulation efficiency was up 20%. The release behavior in vitro of BSA from the nanoparticles was also investigated. We could find that the BSA release from the CKGM‐CS nanoparticles is much more influenced by the CS coating layer than by the CKGM inner structure. And the CKGM‐CS matrices not only exhibited pH‐responsive properties, but ionic strength‐sensitive properties. These systems may present a potential for pulsatile protein drug delivery. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 72B: 299–304, 2005