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High release of antibiotic from a novel hydroxyapatite with bimodal pore size distribution
Author(s) -
Hasegawa Masahiro,
Sudo Akihiro,
Komlev Vladimir S.,
Barinov Serguei M.,
Uchida Atsumasa
Publication year - 2004
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.30047
Subject(s) - materials science , porosity , distilled water , gelatin , antibiotics , in vivo , adsorption , composite material , biomedical engineering , chromatography , chemistry , medicine , organic chemistry , biochemistry , microbiology and biotechnology , biology
We developed a novel hydroxyapatite (HA) cylinder (HA‐A) and compared the slow release of antibiotic in vitro as well as osteoconduction of the material in vivo to a commercially produced porous hydroxyapatite cylinder (HA‐B). HA‐A (4 × 4 mm) was synthesized by mixing HA powder, gelatin, and vegetable oil. The material had a bimodal pore size distribution, with intragranular (10 nm to 10 μm) and intergranular (100 μm) pores, and porosity of 40 vol %, while HA‐B had pore sizes ranging from 50 to 300 μm and identical porosity. In vitro drug release was tested using antibiotics (isepamicin sulfate, vancomycin hydrochloride, and flomoxef sodium) soaked on the HA cylinders using a vacuum system. The mean adsorption efficiency was higher for HA‐A (46%) than for HA‐B (26%) and higher levels of antibiotic were released from HA‐A. Of the antibiotics, ISP showed the longest release duration. Bone ingrowth into the pores was observed for both materials. Because the novel HA showed both the slower release of antibiotic (nanosize pores) and supported excellent osteoconduction (microsize pores), it could be useful for the treatment of osteomyelitis. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 70B: 332–339, 2004