Formation of defined microporous 3D structures starting from cross‐linked hydrogels | Zendy

Barbucci Rolando | Zendy; Leone Gemma | Zendy

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Formation of defined microporous 3D structures starting from cross‐linked hydrogels

Author(s) -

Barbucci Rolando,

Leone Gemma

Publication year - 2003

Publication title -

journal of biomedical materials research part b: applied biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.665

H-Index - 108

eISSN - 1552-4981

pISSN - 1552-4973

DOI - 10.1002/jbm.b.20005

Subject(s) - self healing hydrogels , microporous material , materials science , porosity , scanning electron microscope , chemical engineering , fourier transform infrared spectroscopy , morphology (biology) , composite material , polymer chemistry , biology , engineering , genetics

A new and simple technique was developed to obtain polysaccharide (hyaluronane, alginate and carboxymethylcellulose) ‐based hydrogels with a defined porous morphology. The technique consists of stratifying a cross‐linked hydrogel on a filter with known pore diameter. CO 2 bubbles, produced by the addition of HCl to a porogen salt NaHCO 3 , are forced to pass through the filter, and they induce the hydrogel to assume a porous morphology. The presence and distribution of pores was confirmed by scanning‐electron microscopy (SEM). A strict correspondence was found between the porosity of the filter and the pore diameter in the hydrogels. Water uptake measurements showed a decreased amount of water taken up by the porous hydrogels compared with the native hydrogels, due to a compacting of the material. An explanation of the porous material properties of Hyal hydrogel was given on the basis of FTIR spectra. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 68B: 117–126, 2004

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