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Antibiotic bone cement for the treatment of pseudomonas aeruginosa in joint arthroplasty: Comparison of tobramycin and gentamicin‐loaded cements
Author(s) -
Scott Christopher P.,
Higham Paul A.
Publication year - 2002
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.10515
Subject(s) - tobramycin , gentamicin , pseudomonas aeruginosa , bone cement , aminoglycoside , cement , antibiotics , microbiology and biotechnology , medicine , bacteria , biology , materials science , composite material , genetics
One hundred clinical isolates of Pseudomonas aeruginosa were collected from 22 medical centers throughout Europe and were challenged with two aminoglycoside‐loaded bone cements, employing a modified in vitro Kirby–Bauer susceptibility model. The results of this study show that Simplex® P with tobramycin exhibits antibacterial activity against 98% of the strains tested, compared to 93% for Palacos with gentamicin. Additionally, for strains that were susceptible to the antibiotic bone cement formulations, the average zone of inhibition produced around the tobramycin‐loaded cement disks was approximately 25% greater than that seen around the gentamicin‐loaded cement disks. This difference was statistically significant ( p ≪ 0.01). Tobramycin‐loaded bone cement is therefore the preferred formulation when addressing Pseudomonas aeruginosa in septic joint arthroplasty. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 64B: 94–98, 2003