Premium
The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size
Author(s) -
Zweers Miechel L.T.,
Grijpma Dirk W.,
Engbers Gerard H.M.,
Feijen Jan
Publication year - 2003
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.10046
Subject(s) - dispersity , particle size , nanoparticle , materials science , biodegradable polymer , polyester , polymer , drug delivery , chemical engineering , particle (ecology) , nanotechnology , polymer chemistry , composite material , oceanography , geology , engineering
In local drug delivery, nanoparticles based on biodegradable polymers can function as vehicles with controlled drug‐release properties. To achieve a well‐controlled drug‐release profile, control over the particle size is of great importance. Therefore, biodegradable polyester nanoparticles were prepared by the salting‐out method. Process variables were varied to study the effect on the particle size. The monodisperse particles obtained were between 100 and 400 nm in size and spherical in shape. It was found that the particle size could be adjusted by varying the preparation conditions upon which the polymer concentration had the most pronounced effect. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 66B: 559–566, 2003