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Alginate hydrogels functionalized with β‐cyclodextrin as a local paclitaxel delivery system
Author(s) -
Omtvedt Line Aanerud,
Kristiansen Kåre Andre,
Strand Wenche Iren,
Aachmann Finn Lillelund,
Strand Berit Løkensgard,
ZaytsevaZotova Daria Sergeevna
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37255
Subject(s) - paclitaxel , self healing hydrogels , drug delivery , materials science , cyclodextrin , drug carrier , solubility , chemistry , organic chemistry , polymer chemistry , nanotechnology , cancer , medicine
Modification of drug delivery materials with beta‐cyclodextrins (β‐CyD) is known to increase solubility of poorly water‐soluble drugs, protect drugs from degradation and sustain release. In this study, we developed a hydrogel drug delivery system for local paclitaxel delivery using the natural polysaccharide alginate functionalized with β‐CyD‐moieties. Paclitaxel was chosen due to its ability to form inclusion complexes with cyclodextrins. The rheological and mechanical properties of the prepared hydrogels were characterized, as well as in vitro release of the paclitaxel and in vitro activity on PC‐3 prostate cancer cells. Introduction of β‐CyD‐moieties into the hydrogel reduces the mechanical properties of the gels compared to nonmodified gels. However, gelation kinetics were not markedly different. Furthermore, the β‐CyD‐modified alginate helped to reduce undesired crystallization of the paclitaxel in the gel and facilitated paclitaxel diffusion out of the gel network. Remarkably, the β‐CyD grafted alginate showed increased capacity to complex paclitaxel compared to free HPβ‐CyD. Release of both paclitaxel and degradation products were measured from the gels and were shown to have cytotoxic effects on the PC‐3 cells. The results indicate that functionalized alginate with β‐CyDs has potential as a material for drug delivery systems.