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Biomimetic sponges improve muscle structure and function following volumetric muscle loss
Author(s) -
Haas Gabriel,
Dunn Andrew,
Madsen Josh,
Genovese Peter,
Chauvin Hannah,
Au Jeffrey,
Ziemkiewicz Natalia,
Johnson David,
Paoli Allison,
Lin Andrew,
Pullen Nicholas,
Garg Koyal
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37212
Subject(s) - isometric exercise , biomedical engineering , materials science , myosin , scaffold , sponge , muscle tissue , myocyte , skeletal muscle , anatomy , medicine , biophysics , biology , botany
Skeletal muscle is inept in regenerating after traumatic injuries such as volumetric muscle loss (VML) due to significant loss of various cellular and acellular components. Currently, there are no approved therapies for the treatment of muscle tissue following trauma. In this study, biomimetic sponges composed of gelatin, collagen, laminin‐111, and FK‐506 were used for the treatment of VML in a rodent model. We observed that biomimetic sponge treatment improved muscle structure and function while modulating inflammation and limiting the extent of fibrotic tissue deposition. Specifically, sponge treatment increased the total number of myofibers, type 2B fiber cross‐sectional area, myosin: collagen ratio, myofibers with central nuclei, and peak isometric torque compared to untreated VML injured muscles. As an acellular scaffold, biomimetic sponges may provide a promising clinical therapy for VML.