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Dual response of osteoblast activity and antibacterial properties of polarized strontium substituted hydroxyapatite—Barium strontium titanate composites with controlled strontium substitution
Author(s) -
Swain Subhasmita,
Bowen Chris,
Rautray Tapash
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37195
Subject(s) - materials science , strontium , composite material , scanning electron microscope , composite number , barium , osteoblast , microstructure , ferroelectricity , dielectric , organic chemistry , in vitro , metallurgy , chemistry , biochemistry , optoelectronics
To mimic the electrical properties of natural bone, controlled strontium substitution of both hydroxyapatite and ferroelectric barium titanate were achieved by mixing in the ratio 30:70 by weight. The composites were characterized by X‐ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy to investigate the phase composition and microstructure of the composites. Unpolarized and polarized strontium hydroxyapatite (SrHA)‐barium strontium titanate (BST) composites with controlled degree of Sr substitution were examined, including 5SrHA‐5BST (5% Sr substitution in both components) and 10SrHA‐10BST composites. The 10SrHA‐10BST composite showed a higher osteoblast activity, as observed from the cell viability studies performed using CCK‐8 assay. The polarized composites showed promise against Staphylococcus aureus bacteria by minimizing the adhesion and growth of bacteria, as compared with their unpolarized counterparts. The polarized 10SrHA‐10BST was found to be superior than all other composites. As a result, the approach of polarization of SrHA‐BST composites has been found to be an effective bone substitute material in controlled enhancement of osteoblast growth with simultaneous reduction of bacterial infection.