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Regeneration of the peripheral nerve via multifunctional electrospun scaffolds
Author(s) -
Ghane Nazanin,
Khalili Shahla,
Nouri Khorasani Saied,
Esmaeely Neisiany Rasoul,
Das Oisik,
Ramakrishna Seeram
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37092
Subject(s) - materials science , regeneration (biology) , nanotechnology , tissue engineering , nanofiber , peripheral nerve , regenerative medicine , surface modification , biomedical engineering , stem cell , anatomy , mechanical engineering , biology , microbiology and biotechnology , medicine , engineering
Over the last two decades, electrospun scaffolds have proved to be advantageous in the field of nerve tissue regeneration by connecting the cavity among the proximal and distal nerve stumps growth cones and leading to functional recovery after injury. Multifunctional nanofibrous structure of these scaffolds provides enormous potential by combining the advantages of nano‐scale topography, and biological science. In these structures, selecting the appropriate materials, designing an optimized structure, modifying the surface to enhance biological functions and neurotrophic factors loading, and native cell‐like stem cells should be considered as the essential factors. In this systematic review paper, the fabrication methods for the preparation of aligned nanofibrous scaffolds in yarn or conduit architecture are reviewed. Subsequently, the utilized polymeric materials, including natural, synthetic and blend are presented. Finally, their surface modification techniques, as well as, the recent advances and outcomes of the scaffolds, both in vitro and in vivo, are reviewed and discussed.