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The degradation behavior of calcium‐rich hydroxyapatite foams in vitro
Author(s) -
Zhang Qinghao,
Wang Wenfu,
Schmelzer Eva,
Gerlach Jörg,
Liu Changsheng,
Nettleship Ian
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37077
Subject(s) - materials science , calcium , biomaterial , degradation (telecommunications) , calcium carbonate , calcium nitrate , emulsion , chemical engineering , solubility , biophysics , composite material , nanotechnology , metallurgy , chemistry , telecommunications , organic chemistry , computer science , engineering , biology
Hydroxyapatite (HA) is a well‐known regenerative biomaterial. However, the slow degradation rate of HA is still an obstacle in clinical applications. In this study, we concentrated on investigating the degradation behavior of the calcium‐rich HA foams, which had a demonstrated effect on blood differentiation in previous studies. The HA foams were processed by an emulsion method and were infiltrated with calcium nitrate to create a calcium carbonate second phase, heterogeneously distributed on and under the surface of the foam. During the 28‐day solubility test, the calcium carbonate phase contributed to enhanced Ca 2+ ion release into the saline compared to phase pure HA foams. Both types of foams were biocompatible as demonstrated by human endothelial cell culture on their surface. The release of calcium ions, the degradation behavior, and the endothelial cell differentiation behavior suggest this biphasic ceramic is a candidate for bone marrow in vitro culture and a possible bone substitute material.