Premium
Antibacterial activity of nitric oxide‐releasing carboxymethylcellulose against periodontal pathogens
Author(s) -
Feura Evan S.,
Yang Lei,
Schoenfisch Mark H.
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37056
Subject(s) - aggregatibacter actinomycetemcomitans , porphyromonas gingivalis , biofilm , nitric oxide , microbiology and biotechnology , in vitro , periodontal disease , antibacterial activity , streptococcus mutans , bacteria , chemistry , periodontitis , biology , medicine , dentistry , biochemistry , genetics , organic chemistry
The prevalence of periodontal disease poses a significant global health burden. Treatments for these diseases, primarily focused on removal and eradication of dental plaque biofilms, are challenging due to limited access to periodontal pockets where these oral pathogens reside. Herein, we report on the development and characterization of nitric oxide (NO)‐releasing carboxymethylcellulose (CMC) derivatives and evaluate their in vitro bactericidal efficacy against planktonic Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans , two prominent periodontopathogens. Bactericidal exposure assays revealed that three of the synthesized NO‐releasing polymers were capable of reducing bacterial viability of both species by 99.9% in 2 hr at concentrations of 4 mg ml −1 or lower, reflecting NO's potent and rapid bactericidal action. The NO‐releasing CMCs elicited minimal toxicity to human gingival fibroblasts at their bactericidal concentrations following 24‐hr exposure.