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Preparation and characteristics of a novel oxygen‐releasing coating for improved cell responses in hypoxic environment
Author(s) -
Jiang Yuyin,
Xie Youtao,
Chen Zhaoming,
Li Kai,
Zheng Xuebin
Publication year - 2021
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.37020
Subject(s) - materials science , oxygen , bone healing , oxygen delivery , coating , reactive oxygen species , hypoxia (environmental) , oxygen deficiency , glycolic acid , biomedical engineering , lactic acid , microbiology and biotechnology , nanotechnology , biology , chemistry , medicine , bacteria , anatomy , organic chemistry , genetics
Affected by environmental factors such as oxygen deficiency, the secretion of growth factor was abnormal in bone injury sites, resulting in the poor responses of osteoblasts and prolonging the healing process. Herein, in this study, we reported an in situ oxygen‐releasing porous titanium coating that combines the dual degradability of poly(lactic‐co‐glycolic acid) with the self‐releasing oxygen capacity of the CaO 2 core. The resulting formulation exhibited stable oxygen‐releasing capacity as well as the ability to promote proliferation and differentiation of the MC3T3 cell line under hypoxia conditions. According to these results, oxygen‐releasing coatings based on improved cellular microenvironment may be a promising bone repair material that would reduce the incidence of difficult bone healing in the future.