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Thermal treatment stimulus on erythrocyte compatibility and hemostatic behavior of one‐dimensional bioactive nanostructures
Author(s) -
Shivalingam Chitra,
Purushothaman Bargavi,
R Riju Chandran,
Subramanium Balakumar
Publication year - 2020
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36985
Subject(s) - materials science , biocompatibility , nanomaterials , bioactive glass , chemical engineering , annealing (glass) , nanotechnology , biomedical engineering , composite material , metallurgy , medicine , engineering
This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step annealed at 550 and 600°C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle‐like and rod‐like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO 4 , Na 2 Ca 2 Si 3 O 9 , and Na 1.8 Ca 1.1 Si 6 O 14 were observed for all the bioactive materials, whereas in the case of 800°C, phase transition of Na 3 CaPSiO 7 was perceived along with P 2 O 5 . Alternatively, morphology varied from cubical (600°C) to rod‐like (step annealing) and further turned toward flake‐like (800°C) structures. Step‐annealing process decomposed the nitrate groups as well as maintained the glass network without altering the crystalline phases. As a result, bioactive nanomaterials subjected to step annealing at 550°C along with 600°C exhibited superior compatibility with erythrocytes. Bioglass heat treated at 800°C revealed incredible blood clotting efficacy, in which Ca 2+ ions initiated the thrombotic effect, blood components were concentrated due to the effect of calcium, and enhances the hemostatic performance. Bioactive glass annealed below 800°C facilitates the biocompatibility, subsequently encourage bone ingrowths at in vivo. Bioglass‐800°C inspired the fibrin formation and induced clot as a hemostat to control hemorrhage.