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Specific angiogenic peptide binding with injectable cardiac ECM collagen gel promotes the recovery of myocardial infarction in rat
Author(s) -
Feng Manman,
Liu Xinyu,
Hou Xianglin,
Chen Jixuan,
Zhang Hong,
Song Siqi,
Han Xiaohua,
Shi Chunying
Publication year - 2020
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36951
Subject(s) - myocardial infarction , extracellular matrix , peptide , angiogenesis , apoptosis , receptor , pharmacology , microbiology and biotechnology , materials science , biology , cancer research , medicine , biochemistry
Restoring blood supply is an effective way for the therapy of myocardial infarction (MI). It was reported a specific angiogenic peptide (VMP) derived from vascular endothelial growth factor (VEGF) could activate its receptor to mimic the biological activity of VEGF. In this study, in order to improve the local concentration in infarction region, a collagen‐binding domain was synthesized with VMP to construct collagen binding domain (CBD)‐VMP peptides. The fused CBD‐VMP could bind specifically to collagen which was rich in cardiac extracellular matrix (c‐ECM), without impacting the biological activity of VMP peptides. When the CBD‐VMP peptides loaded on collagen scaffold and implanted into the rats subcutaneously, significant vascularization was observed. Then, CBD‐VMP peptides binding with injectable c‐ECM injected into the MI rat by intramuscular administration, significant blood vessels regeneration, and decrease of cell apoptosis were observed, that corelated with the recovery of cardiac function. It might be an alternative promising strategy for the clinical application of MI.