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Microemulsion and bovine serum albumin nanoparticles as a novel hybrid nanocarrier system for efficient multifunctional drug delivery
Author(s) -
Gharbavi Mahmoud,
Danafar Hossein,
Sharafi Ali
Publication year - 2020
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36935
Subject(s) - nanocarriers , drug delivery , materials science , biocompatibility , paclitaxel , cytotoxicity , bovine serum albumin , in vivo , microemulsion , conjugate , nanotechnology , pharmacology , in vitro , chemistry , chromatography , biochemistry , biology , pulmonary surfactant , mathematical analysis , microbiology and biotechnology , mathematics , chemotherapy , metallurgy , genetics
The present study aims to: (a) design the versatile microemulsions (MEs) system for drug delivery; (b) use the bovine serum albumin nanoparticles for MEs system development; (c) characterize the physicochemical properties, cytotoxicity, and biocompatibility of the modified MEs (MMEs) system; (d) load of paclitaxel (PTX) and folate conjugate of MEs system; and (e) assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity, and stability of MMEs system were characterized. The results of our study show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible, and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system.