Effect of scaffold properties on adhesion and maintenance of boundary cap neural crest stem cells in vitro | Zendy

Han Yilin | Zendy; Baltriukienė Daiva | Zendy; Kozlova Ele. | Zendy

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Effect of scaffold properties on adhesion and maintenance of boundary cap neural crest stem cells in vitro

Author(s) -

Han Yilin,

Baltriukienė Daiva,

Kozlova Ele.

Publication year - 2020

Publication title -

journal of biomedical materials research part a

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.849

H-Index - 150

eISSN - 1552-4965

pISSN - 1549-3296

DOI - 10.1002/jbm.a.36900

Subject(s) - stem cell , scaffold , neural crest , microbiology and biotechnology , materials science , tissue engineering , biomedical engineering , population , in vitro , neural stem cell , adult stem cell , chemistry , biology , endothelial stem cell , biochemistry , engineering , medicine , embryo , environmental health

Optimal combination of stem cells and biocompatible support material is a promising strategy for successful tissue engineering. The required differentiation of stem cells is crucial for functionality of engineered tissues and can be regulated by chemical and physical cues. Here we examined how boundary cap neural crest stem cells (bNCSCs) are affected when cultured in the same medium, but on collagen‐ or laminin‐polyacrylamide (PAA) scaffolds of different stiffness (0.5, 1, or ~7 kPa). bNCSCs displayed marked differences in their ability to attach, maintain a large cell population and differentiate, depending on scaffold stiffness. These findings show that the design of physical cues is an important parameter to achieve optimal stem cell properties for tissue repair and engineering.

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