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Novel dual‐responsive semi‐interpenetrating polymer network hydrogels for controlled release of anticancer drugs
Author(s) -
Dadfar Seyed Mohammad Reza,
Pourmahdian Saeed,
Tehranchi Mohammad Mehdi,
Dadfar Seyed Mohammadali
Publication year - 2019
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36741
Subject(s) - self healing hydrogels , doxorubicin hydrochloride , materials science , interpenetrating polymer network , polymer , drug delivery , radical polymerization , polymerization , nanogel , controlled release , doxorubicin , nuclear chemistry , chemical engineering , polymer chemistry , nanotechnology , chemistry , composite material , medicine , surgery , engineering , chemotherapy
Novel dual‐responsive hydrogels of semi‐interpenetrating polymer networks (semi‐IPNs) based on temperature‐sensitive N ‐isopropylacrylamide (NIPAA) and pH‐sensitive N ‐ethylmaleamic acid (NEMA) monomers and sodium alginate polymer were synthesized using free‐radical polymerization in the presence of N , N ′‐methylenebisacrylamide as a crosslinker. Stimuli‐responsive properties of the semi‐IPN hydrogels showed remarkable sensitivity to both temperature and pH without limitation in NEMA content. Doxorubicin hydrochloride (DOX) as a model drug was efficiently loaded into the hydrogels and the release profiles of drug from them were investigated. The results of in vitro studies showed a quick DOX release in the conditions simulating tumor environment (phosphate‐buffered saline [PBS], pH 6.5, 37°C) or endosomes/lysosomes (PBS, pH 5.5, 37°C) compared to simulated human physiological conditions (PBS, pH 7.4, 37°C). In conclusion, the novel poly(NIPAA‐co‐NEMA) semi‐IPN hydrogels could be a promising candidate for targeted and controlled release of anticancer drugs in drug delivery system.