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Enhanced osteogenic differentiation of mesenchymal stem cells on metal–organic framework based on copper, zinc, and imidazole coated poly‐ l ‐lactic acid nanofiber scaffolds
Author(s) -
Telgerd M. D.,
Sadeghinia Mohammad,
Birhanu Gebremariam,
Daryasari M. P.,
ZandiKarimi Ali,
Sadeghinia Ali,
Akbarijavar Hamid,
Karami M. H.,
Seyedjafari Ehsan
Publication year - 2019
Publication title -
journal of biomedical materials research part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.849
H-Index - 150
eISSN - 1552-4965
pISSN - 1549-3296
DOI - 10.1002/jbm.a.36707
Subject(s) - materials science , mesenchymal stem cell , zinc , nanofiber , adipose tissue , tissue engineering , imidazole , lactic acid , biomedical engineering , nanotechnology , chemistry , biochemistry , microbiology and biotechnology , metallurgy , biology , medicine , genetics , bacteria
The presence of inorganic bioactive minerals with polymers can accelerate and promote several processes including: bone cell joining, proliferation, differentiation, and expression of osteogenic proteins. In this study, zinc (Zn), copper (Cu), and imidazole metal–organic framework (MOF) nanoparticles were synthesized and coated over poly‐ l ‐lactic acid (PLLA) nanofibrous scaffolds for bone tissue engineering application. The surface and bioactive features of the scaffolds were characterized. The osteogenic potential of the scaffolds on human adipose tissue‐derived mesenchymal stem cells (MSCs) was evaluated. Zn–Cu imidazole MOF coated PLLA scaffolds (PLLA@MOF) showed a comparable rate of MSC proliferation with the pure PLLA scaffolds and tissue culture plate (TCP). However, the PLLA@MOF potential of osteogenic differentiation was significantly greater than either pristine PLLA scaffolds or TCP. Hence, coating Zn–Cu imidazole MOF has a significant effect on the osteogenesis of MSC. Therefore, PLLA@MOF is novel scaffolds with bioactive components which are crucial for osteoconductivity and also able to provoke the osteogenesis and angiogenesis.